Raffaella Klima

Targeting hypoxia-responsive miR-155-5p and miR-210-3p restores alveolar regeneration and reverses pulmonary fibrosis

This study identifies miR-155-5p and miR-210-3p as regulators of alveolar regeneration in IPF, showing their inhibition restores epithelial repair and reverses fibrosis in mice.

AAV-miR-124 enhances endogenous alveolar epithelial regenerative plasticity and reverses bleomycin-induced pulmonary fibrosis

This study identifies miR-124-3p as a promoter of alveolar epithelial transdifferentiation and shows that AAV-delivered miR-124 reduces bleomycin-induced pulmonary fibrosis in mice.

Molecular Profiling and High-Content Drug Screening of Metastatic Colorectal Cancer Organoids Reveal Evolutionary Mechanisms of Pan-KRAS Inhibitor Resistance

This study uses patient-derived organoids and single-cell RNA sequencing to investigate resistance mechanisms to pan-KRAS inhibitors in metastatic colorectal cancer.

Drug-repurposing screen identifies thiostrepton as a novel regulator of the tumor suppressor DAB2IP

The paper screens FDA-approved drugs to find those that increase DAB2IP protein levels, identifying thiostrepton as a potential anti-cancer agent that relies on DAB2IP for its tumor-suppressive effect.

TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila brains

This study shows that TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila brains, and that modulating GABA neurotransmission can reverse locomotion defects in TDP-43-deficient flies.

TDP-43 regulates the expression levels of Disc-large in skeletal muscles to promote the assemble of the neuromuscular synapses in Drosophila

This study shows TDP-43 promotes neuromuscular synapse formation in Drosophila by regulating Disc-large expression, with similar mechanisms observed in human ALS tissues.