Bulk delivery of a preassembled apical surface initiates epithelial lumen formation
Sujasha Ghosh, Eleanor R. Martin, Yuhong Chen, Natasha Amiera, Samaksh Singh, Kay En Low, Rossana Girardello, Barbara Hübner, Gunnar A. G. Dittmar, Alexander Ludwig
The paper identifies VACs as specialized transport organelles delivering a preassembled apical cortex to the AMIS, enabling lumen initiation, and highlights PatJ's role in coordinating this process with cell-cell junctions.
Nature Communications · Aug 7, 2026Peer-reviewedCell Biology