Neural excitation/inhibition imbalance and the treatment of severe depression
Freek ten Doesschate, Willem B. Bruin, Peter Zeidman, Chris Abbott, Miklós Árgyelán, Annemiek Dols, Louise Emsell, Philip van Eijndhoven, Eric R. van Exel, Peter C.R. Mulders, Katherine L. Narr, Indira Tendolkar, Didi Rhebergen, Pascal A. Sienaert, Mathieu Vandenbulcke, , Guido Alexander van Wingen
This study investigates the relationship between neural excitation/inhibition imbalance and treatment outcomes in severe depression, finding that ECT effectiveness is not tied to changes in inhibition but can be enhanced by pharmacotherapy under specific conditions.
bioRxiv · Jul 9, 2021 · PreprintNeuroscience