Author

Willem B. Bruin

Amsterdam NeuroscienceORCID 0000-0002-0672-8903Unclaimed ORCID profile · follow to get notified of new preprints

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:imaging· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Guido Alexander van WingeniD· 3 shared Anders Lillevik ThorseniD· 2 shared Bjarne K. A. HanseniD· 2 shared Carles Soriano‐MasiD· 2 shared Chris VriendiD· 2 shared Dan Joseph SteiniD· 2 shared Daniela Rodriguez-ManriqueiD· 2 shared Emily R. SterniD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Guido Alexander van WingenORCID

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3 papers

Recent·Most cited

Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium

Nadža Džinalija, Odile A. van den Heuvel, Helen Blair Simpson, Iliyan Ivanov, Ana Isabel Araújo, Srinivas Balachander, Jan Carl Beucke, Daniel Brandeis, Silvia Brem, Willem B. Bruin, Jan K. Buitelaar, Miguel S. Castelo-Branco, 최선아, Goi Khia Eng, Sophie Fitzsimmons, , Ilya Milos Veer

This study analyzes fMRI data from OCD patients and controls to identify age-specific differences in brain activation during inhibitory control and error processing.

Biological Psychiatry · Oct 1, 2026Peer-reviewedNeuroscience

Mapping Higher-Order Topology in OCD Brain Networks with Hodge Laplacian

Hanyang Ruan, Moo K Chung, Willem B. Bruin, Nadža Džinalija, Yoshinari Abe, P. Alonso, Alan Anticevic, Srinivas Balachander, Marcelo C. Batistuzzo, Francesco Benedetti, Sara Bertolín, Silvia Brem, Youngsun Cho, Federica Colombo, Beatriz Couto, , Kathrin Koch

This paper introduces a Hodge-Laplacian framework to analyze higher-order topology in OCD brain networks, identifying loop-level abnormalities not detectable by conventional functional connectivity analysis.

bioRxiv · Jun 24, 2026 · PreprintNeuroscience

Neural excitation/inhibition imbalance and the treatment of severe depression

Freek ten Doesschate, Willem B. Bruin, Peter Zeidman, Chris Abbott, Miklós Árgyelán, Annemiek Dols, Louise Emsell, Philip van Eijndhoven, Eric R. van Exel, Peter C.R. Mulders, Katherine L. Narr, Indira Tendolkar, Didi Rhebergen, Pascal A. Sienaert, Mathieu Vandenbulcke, , Guido Alexander van Wingen

This study investigates the relationship between neural excitation/inhibition imbalance and treatment outcomes in severe depression, finding that ECT effectiveness is not tied to changes in inhibition but can be enhanced by pharmacotherapy under specific conditions.

bioRxiv · Jul 9, 2021 · PreprintNeuroscience