Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models
Alexia K. Martin, Jack Hedberg, Ilse Hernandez-Aguirre, Uksha Saini, Do‐Yeon Kim, Yeaseul Kim, Ravi Dhital, Kevin A. Cassady
This study develops an oncolytic HSV expressing IL-27 (C027) that improves survival in syngeneic glioma models by enhancing CD8 T cell function and inducing durable immune memory.
Journal for ImmunoTherapy of Cancer · Jul 1, 2025Peer-reviewedImmunology