Coupled myovascular expansion directs cardiac growth and regeneration
Paige DeBenedittis, Anish Karpurapu, Albert Henry, Michael C. Thomas, Timothy J. McCord, Kyla Brezitski, Anil Prasad, Caroline E. Baker, Yoshihiko Kobayashi, Svati Hasmukh Shah, Christopher D. Kontos, Purushothama Rao Tata, R Thomas Lumbers, Ravi Karra
This study shows that coupled proliferation of cardiac endothelial cells and cardiomyocytes is essential for heart growth and regeneration, mediated by VEGF-VEGFR2 signaling.
Development · Sep 15, 2022Peer-reviewedDevelopmental Biology