Purushothama Rao Tata

This study identifies PDGFA-expressing alveolar type 1 cells as a tonic niche organizer that maintains alveolar homeostasis by restraining fibroblast activation and promoting tissue repair.

The paper identifies CYP2B10 as the enzyme that activates BHT into a toxic quinone methide, leading to apoptosis and lung damage in mice.

The paper identifies TP53 activation in alveolar epithelial cells as a driver of cell extrusion and tissue remodeling in IPF through bidirectional lineage plasticity.

The paper identifies region-specific molecular regulatory programs in human distal airways that maintain epithelial identity and mucus homeostasis, revealing mechanisms for mucociliary defense.

This paper presents a single-cell and spatial proteotranscriptomic atlas of human oral tissues, identifying fibroblasts as key immunoregulatory hubs and revealing changes in disease states.

This study shows that a bleomycin-induced lung injury model in ferrets shares key pathophysiological, cellular, and molecular features with human idiopathic pulmonary fibrosis, suggesting its use for IPF research.

USHER corrects out-of-distribution biases in foundation models by transforming embeddings to a reference space, improving cross-platform integration and downstream tasks.

The paper identifies mechanoenhancers that regulate transcription in response to matrix stiffness and shows their potential for reprogramming cellular responses to mechanical cues.

The paper identifies Cdh4+ dermal fibroblasts in pregnant mice that convert mechanical signals to chemical signals to promote epidermal stem cell proliferation during skin expansion.

SAME improves multimodal spatial omics integration by allowing topological disruptions during alignment, enhancing cell-type accuracy and revealing hidden biological insights.

This study reveals how persistent intracellular bacterial macromolecules in mucosal epithelial cells drive inflammatory signaling, offering new insights into microbial-host interactions and their potential impact on inflammatory disease treatment and drug efficacy.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

The paper develops a machine learning tool to predict S-palmitoylation sites on transmembrane proteins, identifying new candidates and demonstrating its utility in design.

The paper introduces Acyl-Trap, a modified suspension trap assay for detecting and quantifying S-acylated proteins with low input, and identifies new S-acylation sites in mouse brain.

This study shows that coupled proliferation of cardiac endothelial cells and cardiomyocytes is essential for heart growth and regeneration, mediated by VEGF-VEGFR2 signaling.

The paper identifies a novel secretory-like cell type in the developing human lung that gives rise to pulmonary neuroendocrine cells and multiciliated cells.

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.