Author

Christopher D. Kontos

Duke UniversityORCID 0000-0002-8056-3115Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

James C. OttoiD· 2 shared Kaileen FeiiD· 2 shared Kevin W. SoutherlandiD· 2 shared Lindsey A. OlivereiD· 2 shared Qunsheng Dai· 2 shared Yarui DiaoiD· 2 shared Yueyuan XuiD· 2 shared Albert HenryiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

James C. OttoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening Ischemia

Qunsheng Dai, Changxin Wan, Yueyuan Xu, Kaileen Fei, Lindsey A. Olivere, Hana S. Shafique, Shaghayegh Sadeghmousavi, Camryn L. Johnson, Brianna Garrett, Leo Akers, Derek Peters, James C. Otto, Christopher D. Kontos, Zhiceng Ji, Yarui Diao, Kevin W. Southerland

The paper identifies Vcam1+ fibro-adipogenic progenitors as markers of fatty infiltration in chronic limb threatening ischemia using single-cell transcriptomics in mouse models.

JVS Vascular Science · Jan 1, 2025Peer-reviewedGenomics

Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells

Kevin W. Southerland, Yueyuan Xu, Derek Peters, Xiaolin Wei, Xin Lin, Yu Xiang, Kaileen Fei, Lindsey A. Olivere, Jeremy M. Morowitz, James C. Otto, Qunsheng Dai, Christopher D. Kontos, Yarui Diao

This study identifies pro-inflammatory macrophages as a key factor impairing skeletal muscle regeneration in ischemic-damaged limbs by inducing premature differentiation of satellite cells.

Genome Medicine · Nov 10, 2023Peer-reviewedGenomics

Coupled myovascular expansion directs cardiac growth and regeneration

Paige DeBenedittis, Anish Karpurapu, Albert Henry, Michael C. Thomas, Timothy J. McCord, Kyla Brezitski, Anil Prasad, Caroline E. Baker, Yoshihiko Kobayashi, Svati Hasmukh Shah, Christopher D. Kontos, Purushothama Rao Tata, R Thomas Lumbers, Ravi Karra

This study shows that coupled proliferation of cardiac endothelial cells and cardiomyocytes is essential for heart growth and regeneration, mediated by VEGF-VEGFR2 signaling.

Development · Sep 15, 2022Peer-reviewedDevelopmental Biology