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Templated seeding induces the formation of Alzheimer paired helical tau filaments in human brain organoids
Mehtap Bacioglu, Panagiotis Katsinelos, Manuel Schweighauser…·Maria Grazia Spillantini
Cortical organoids from healthy human iPSCs, seeded with Alzheimer brain tau, form three-repeat tau filaments that cryo-EM shows are identical to Alzheimer paired helical filaments and need endogenous tau.