Filomena Gallo

Cortical organoids from healthy human iPSCs, seeded with Alzheimer brain tau, form three-repeat tau filaments that cryo-EM shows are identical to Alzheimer paired helical filaments and need endogenous tau.

This study uses a live-cell autophagy reporter to show that naked mole-rat skin fibroblasts form reversible vacuoles under lysosomal stress, indicating dynamic lysosomal remodelling.

This study characterizes the morphology and molecular behavior of Orientia tsutsugamushi in tick cell lines, revealing distinct replication dynamics and protein expression patterns compared to mammalian cells.

The paper investigates how neural crest cells adapt to physical confinement during migration in zebrafish embryos, finding that nuclear deformation occurs without DNA damage.

The paper shows that tissue spreading during epiboly in chicken embryos reorganizes the extracellular matrix to establish blastoderm architecture and polarity.

This study shows that loss of Rtnl1 in Drosophila disrupts presynaptic ER organization and causes defects in Ca2+ dynamics and neurotransmission.

This study shows that reducing tension in the avian vitelline membrane facilitates proper body axis formation by allowing controlled morphogenesis and preventing developmental defects.