Taxiarchis Katsinelos

Cortical organoids from healthy human iPSCs, seeded with Alzheimer brain tau, form three-repeat tau filaments that cryo-EM shows are identical to Alzheimer paired helical filaments and need endogenous tau.

This study identifies twelve phosphomimetic mutations in tau that induce the formation of paired helical filaments in vitro, mimicking Alzheimer's disease structures.

The paper shows Drosophila melanogaster resist trans-synaptic spread of human tau, suggesting they are not suitable for screening tau propagation modifiers.

The paper investigates whether tau assemblies behave like independently acting prion-like particles in mouse neural tissue and finds that seeding behavior only occurs at supra-physiological concentrations.

The paper shows that microglia phagocytosing neurons with tau aggregates become hypofunctional and release tau seeds, contributing to tauopathy progression.

This study shows that the Hsp70 disaggregation machinery disassembles Tau fibrils, generating small seeding-competent Tau species that can drive aggregation.