FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism
Sneha Shah, Gemma Molinaro, Botao Liu, Ruijia Wang, Kimberly M. Huber, Joel D. Richter
This study shows that FMRP loss reduces ribosome stalling on specific mRNAs, leading to altered H3K36me3 marks and alternative splicing of autism-related genes.
Cell Reports · Mar 1, 2020Peer-reviewedNeuroscience