Author

Joel D. Richter

University of Massachusetts Chan Medical SchoolORCID 0000-0003-2753-2501Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

Botao Liu· 2 shared Ruijia WangiD· 2 shared Suna JungiD· 2 shared Elisa R. DonnardiD· 1 shared Gemma MolinaroiD· 1 shared Huan ShuiD· 1 shared Kimberly M. HuberiD· 1 shared Sneha ShahiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Botao Liu

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 29, 2026

Dysregulation of FMR1 Splicing in Human Fragile X Syndrome

Suna Jung, Joel D. Richter

This study identifies FMR1-217 mis-splicing in FXS as a result of CGG repeat expansion, R-loop formation, and impaired Pol II elongation, with potential therapeutic rescue via splice-switching ASOs.

1 citation

humanmultiome

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Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedNov 16, 2020

FMRP Links Optimal Codons to mRNA stability in Neurons

Huan Shu, Elisa R. Donnard, Botao Liu…·Joel D. Richter

This study shows FMRP stabilizes mRNAs with optimal codons in neurons, linking codon usage to mRNA stability and contributing to FXS pathogenesis.

60 citationstop 3%

mouseRibo-seq

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NeuroscienceCell ReportsPeer-reviewedMar 1, 2020

FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism

Sneha Shah, Gemma Molinaro, Botao Liu…·Joel D. Richter

This study shows that FMRP loss reduces ribosome stalling on specific mRNAs, leading to altered H3K36me3 marks and alternative splicing of autism-related genes.

91 citationstop 1%

mousebulk RNA-seq

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