Author

Zhenhai Li

Shanghai UniversityORCID 0000-0002-0720-2807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biophysics· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:multiome· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Amir Hossein Kazemipour AshkezariiD· 1 shared Cheng ZhuiD· 1 shared Haiyue LiiD· 1 shared Huajian GaoiD· 1 shared Jiayu LiiD· 1 shared Jing LiiD· 1 shared Jung Hun PheeiD· 1 shared Lingchao MaoiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiophysics

Amir Hossein Kazemipour AshkezariORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CD8-mediated organization of the TCR-pMHC interface shapes its force response and dissociation pathways

Jiayu Li, Zhenhai Li

This study uses molecular dynamics simulations to show how CD8 modulates the mechanical stability and dissociation pathways of the TCR-pMHC complex.

bioRxiv · Jun 20, 2026 · PreprintBiophysics

Force-regulated catch bonds and fusion peptide exposure drive coronavirus entry

Haiyue Li, Zhenhai Li, Huajian Gao

This study develops a model to show how mechanical forces regulate coronavirus entry by strengthening ACE2 binding and promoting spike protein disassembly.

bioRxiv · May 22, 2026 · PreprintBiophysics

DynMoCo: a Novel AI Framework to Reveal Modular Substructures of Protein From Molecular Dynamics

Lingchao Mao, Mingu Kwak, Amir Hossein Kazemipour Ashkezari, Zhenhai Li, Peiwen Cong, Yunfeng Chen, Jung Hun Phee, Sooyeon Kang, Jing Li, Cheng Zhu

DynMoCo identifies modular substructures in protein dynamics from molecular simulations by detecting time-evolving communities of residues.

Biophysical Journal · Mar 19, 2026Peer-reviewedBiophysics

Protein-protein interaction prediction via structure-based deep learning

Yucong Liu, Yijun Liu, Zhenhai Li

This study introduces RSPPI, a deep learning framework for predicting protein-protein interactions using structural and sequence data, showing improved cross-species performance over existing methods.

Proteins Structure Function and Bioinformatics · Jun 23, 2024Peer-reviewedBioinformatics