Drp1-mediated mitochondrial fission protects macrophages from mtDNA/ZBP1-mediated sterile inflammation and inhibits post-infarct cardiac remodeling
Yuki Kondo, Jun‐ichiro Koga, Nasanbadrakh Orkhonselenge, Lixiang Wang, Nao Hasuzawa, Shunsuke Katsuki, Tetsuya Matoba, Yosuke Nishimura, Masatoshi Nomura, Masaharu Kataoka
This study shows that Drp1 in macrophages prevents mtDNA release and inflammation, reducing cardiac remodeling after heart attack.
Cardiovascular Research · Jan 1, 2026Peer-reviewedBiochemistry