Febrile temperature enhances Plasmodium falciparum and neutrophil adhesion by disrupting the endothelial glycocalyx
Viola Introini, Rory K. M. Long, Olawunmi Rashidat Oyerinde, María Gestal-Mato, Sílvia Sanz, Iván de Jesús Rizo Álvarez, Letícia Hartmann, Frank Stein, Gyu Min Hwang, Borja López-Gutiérrez, Karl B. Seydel, Gretchen Lano Birbeck, Maria Bernabeu
The paper shows that fever increases adhesion of malaria parasites and neutrophils to brain blood vessels by damaging the endothelial glycocalyx, suggesting antipyretics could reduce disease severity.
bioRxiv · Sep 7, 2025 · PreprintMicrobiology