Author

Borja López-Gutiérrez

European Molecular Biology LaboratoryORCID 0000-0002-7159-5836Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Maria BernabeuiD· 4 shared Alina BatzillaiD· 3 shared Hannah FleckensteiniD· 3 shared Livia PiattiiD· 3 shared Rory K. M. LongiD· 3 shared Sílvia SanziD· 3 shared François KorbmacheriD· 2 shared Fumio NakakiiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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4 shared papersMicrobiology

Maria BernabeuORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

ETS-guided iPSC-endothelial models recapitulate malaria pathogenesis

François Korbmacher, Rory K. M. Long, Hannah Fleckenstein, Patryk Poliński, Dennis Crusius, Livia Piatti, Borja López-Gutiérrez, Alina Batzilla, Vikas Trivedi, Miki Ebisuya, Maria Bernabeu

This study develops an iPSC-based model with enhanced endothelial identity to study malaria parasite interactions and pathogenesis in vitro.

EMBO Molecular Medicine · Jun 13, 2026Peer-reviewedMicrobiology

Innate immune responses to Plasmodium falciparum disrupt the blood-brain barrier

Alina Batzilla, Pia Dernick, Jon Bezney, Andreas R. Gschwind, Fumio Nakaki, Mireia Altadill, Hannah Fleckenstein, Livia Piatti, Sílvia Sanz, Manuel Fiegl, Olawunmi Rashidat Oyerinde, Borja López-Gutiérrez, Miguel López‐Botet, James A. Sharpe, Lars Michael Steinmetz, , Maria Bernabeu

The paper investigates how innate immune responses to Plasmodium falciparum contribute to blood-brain barrier disruption in cerebral malaria using an in vitro model.

bioRxiv · Oct 20, 2025 · PreprintImmunology

Febrile temperature enhances Plasmodium falciparum and neutrophil adhesion by disrupting the endothelial glycocalyx

Viola Introini, Rory K. M. Long, Olawunmi Rashidat Oyerinde, María Gestal-Mato, Sílvia Sanz, Iván de Jesús Rizo Álvarez, Letícia Hartmann, Frank Stein, Gyu Min Hwang, Borja López-Gutiérrez, Karl B. Seydel, Gretchen Lano Birbeck, Maria Bernabeu

The paper shows that fever increases adhesion of malaria parasites and neutrophils to brain blood vessels by damaging the endothelial glycocalyx, suggesting antipyretics could reduce disease severity.

bioRxiv · Sep 7, 2025 · PreprintMicrobiology

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

Livia Piatti, Alina Batzilla, Fumio Nakaki, Hannah Fleckenstein, François Korbmacher, Rory K. M. Long, Daniel Schraivogel, John A. Hawkins, Tais Romero-Uruñuela, Borja López-Gutiérrez, Sílvia Sanz, Yannick Schwab, Lars Michael Steinmetz, James A. Sharpe, Maria Bernabeu

This study shows that Plasmodium falciparum egress products disrupt BBB endothelial junctions and activate JAK-STAT signaling, leading to increased permeability and suggesting therapeutic targets.

Nature Communications · Aug 6, 2025Peer-reviewedMicrobiology