Itzel Nissen

Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis

The paper identifies gene regulatory networks linked to GABA signaling in glioblastoma using multi-omics data and machine learning, showing GABA signaling promotes tumor growth through non-synaptic mechanisms.

Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication

This study maps the promoter-enhancer interactome and regulatory landscape in glioblastoma, revealing rewiring of chromatin interactions and gene expression changes related to synaptic communication.