Agnete Kirkeby

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease

The paper investigates TE transcription in Parkinson's disease brains, finding region- and cell-type-specific TE activation linked to an interferon response in microglia and neurons.

Generation of human appetite-regulating neurons and tanycytes from stem cells

This study generates human appetite-regulating neurons and tanycytes from stem cells, identifying key progenitor markers and signaling mechanisms for hypothalamic subregion specification.

Decoding morphogen patterning of human neural organoids with a multiplexed single-cell transcriptomic screen

The paper uses a multiplexed single-cell transcriptomic screen to study how morphogen cues affect regional specification in human neural organoids, finding that timing, concentration, and combination of morphogens strongly influence cell type and regional composition.

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

This study shows that L1 retrotransposons influence human pluripotency exit and early brain development through their expression and derived transcripts.

Mapping early patterning events in human neural development usingan in-vitro microfluidic stem cell model

The paper uses a microfluidic stem cell model to study early human neural patterning, identifying regional specification and fate determination during the epiblast stage.

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia.

The paper identifies three neuron-specific schizophrenia protein networks enriched for genetic and transcriptional perturbations and validates their disruption in 22q11.2 deletion carriers.

Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis

The paper identifies gene regulatory networks linked to GABA signaling in glioblastoma using multi-omics data and machine learning, showing GABA signaling promotes tumor growth through non-synaptic mechanisms.

Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson's disease

This study identifies FGF17 as a potent inducer of ventral midbrain dopaminergic progenitors, which can functionally rescue motor deficits in a rat Parkinson's disease model.

Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

Ribosomal RNA 2'-O-methylation dynamics impact cell fate decisions

The paper examines how changes in rRNA 2'-O-methylation during development and differentiation affect cell fate decisions in mouse and human cells.

Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendroglia

The paper uses snRNA-seq to analyze TBI brain tissue, finding oligodendroglia activate endogenous retroviruses, linking them to neuroinflammation.

Neural tube patterning: from a minimal model for rostrocaudal patterning towards an integrated 3D model

The paper presents a minimal gene regulatory model for rostrocaudal neural tube patterning and integrates it with a dorsoventral model to predict 3D patterning and sensitivity to morphogen levels.

Single Cell Gene Expression Analysis Reveals Human Stem Cell-Derived Graft Composition in a Cell Therapy Model of Parkinson’s Disease

The paper uses scRNA-seq to analyze graft composition in a Parkinson’s disease cell therapy model, revealing differences between human stem cell-derived and fetal tissue grafts.