Author

Lorena Varela

University of KentORCID 0000-0002-0743-9441Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Angela Serrano-Sanchez· 1 shared Encarnación Medina‐CarmonaiD· 1 shared Felipe OssaiD· 1 shared Gary S. ThompsoniD· 1 shared Jack Bragg· 1 shared Jose‐Luis Ortega RoldaniD· 1 shared Joseph Cassar· 1 shared Vahitha B. Abdul‐SalamiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

Angela Serrano-Sanchez

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1 paper

Recent·Most cited

Mechanistic Elucidation of CLIC1 Membrane Insertion via Structural and Dynamic Modulation

Joseph Cassar, Angela Serrano-Sanchez, Jack Bragg, Encarnación Medina‐Carmona, Felipe Ossa, Gary S. Thompson, Vahitha B. Abdul‐Salam, Lorena Varela, Jose‐Luis Ortega Roldan

This study elucidates the mechanism of CLIC1 membrane insertion through structural and dynamic analysis, revealing Zn2+-induced conformational changes and oligomerization as critical steps.

bioRxiv · Jan 19, 2025 · PreprintBiochemistry