Author

Felipe Ossa

Imperial College LondonORCID 0000-0002-3968-6447Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Approach:biophysical modeling· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

Angela Serrano-Sanchez· 2 shared Encarnación Medina‐CarmonaiD· 2 shared Jose‐Luis Ortega RoldaniD· 2 shared Noor Limmer· 2 shared Theodoros K. KaramanosiD· 2 shared Vahitha B. Abdul‐SalamiD· 2 shared Abdelaziz El‐HamdaouiiD· 1 shared Arnout P. Kalverda· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

Angela Serrano-Sanchez

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4 papers

Recent·Most cited

Accurate interdomain contacts in mixed folded proteins from NMR-guided coarse-grained simulations

Billy Hobbs, Noor Limmer, Gwendolyn L. Clenshaw, Felipe Ossa, Theodoros K. Karamanos

The paper improves the accuracy of interdomain contacts in mixed folded-disordered proteins using NMR-guided coarse-grained simulations.

Physical Chemistry Chemical Physics · Jan 1, 2026Peer-reviewedBiophysics

A low-complexity linker as a driver of intra- and intermolecular interactions in DNAJB chaperones

Billy Hobbs, Noor Limmer, Felipe Ossa, Ella Knüpling, Samuel Lenton, Vito Foderà, Arnout P. Kalverda, Theodoros K. Karamanos

This study investigates the role of the GF-linker in DNAJB chaperones, showing its involvement in autoinhibition and its interaction with Hsc70.

Nature Communications · May 31, 2025Peer-reviewedBiophysics

Mechanistic Elucidation of CLIC1 Membrane Insertion via Structural and Dynamic Modulation

Joseph Cassar, Angela Serrano-Sanchez, Jack Bragg, Encarnación Medina‐Carmona, Felipe Ossa, Gary S. Thompson, Vahitha B. Abdul‐Salam, Lorena Varela, Jose‐Luis Ortega Roldan

This study elucidates the mechanism of CLIC1 membrane insertion through structural and dynamic analysis, revealing Zn2+-induced conformational changes and oligomerization as critical steps.

bioRxiv · Jan 19, 2025 · PreprintBiochemistry

Structure-based discovery and in vitro validation of selective inhibitors of Chloride Intracellular Channel 4 protein.

Fisayo Andrew Olotu, Encarnación Medina‐Carmona, Angela Serrano-Sanchez, Felipe Ossa, Abdelaziz El‐Hamdaoui, Özlem Taştan Bishop, Jose‐Luis Ortega Roldan, Vahitha B. Abdul‐Salam

This study identifies and validates FDA-approved drugs as inhibitors of CLIC4 using structural bioinformatics and experimental assays.

Computational and Structural Biotechnology Journal · Dec 24, 2022Peer-reviewedMolecular Biology