Jose‐Luis Ortega Roldan

This study elucidates the mechanism of CLIC1 membrane insertion through structural and dynamic analysis, revealing Zn2+-induced conformational changes and oligomerization as critical steps.

The paper shows that mutations in glutamine synthetase can rescue a proline biosynthesis block by leaking a phosphorylated intermediate, enabling a new pathway and organismal adaptation.

This study identifies and validates FDA-approved drugs as inhibitors of CLIC4 using structural bioinformatics and experimental assays.