Structural studies of the C-terminal cysteine-rich domain of Aedes albopictus vitellogenin reveal an evolutionarily divergent, monomeric C-terminal cysteine knot (CTCK) architecture
M Berlinguer, Mahdieh Sadeghichehelgaz, Alice Vetrano, Alessandro D'Aquilio, Ferdinando Mercuri, Marta Villa, Paolo Gabrieli, Claudio Iacobucci, Federico Forneris
This study determines the crystal structure of the C-terminal cysteine knot domain of Aedes albopictus vitellogenin, revealing a monomeric, evolutionarily divergent architecture that challenges prior assumptions about its oligomerization role.
bioRxiv · May 26, 2026 · PreprintMolecular Biology