Requirements for efficient endosomal escape by designed mini-proteins
Jonathan Giudice, Daniel D. Brauer, Madeline Zoltek, Ángel L. Vázquez-Maldonado, Mark J. S. Kelly, Alanna Schepartz
This paper identifies the requirements for efficient endosomal escape by ZF5.3, a mini-protein, showing pH-induced unfolding and lipid-BMP interaction are critical for its function.
bioRxiv · Apr 5, 2024 · PreprintBiochemistry