Ángel L. Vázquez-Maldonado

This paper develops Shedders, bispecific antibodies that recruit ADAM10 to induce ectodomain shedding of cell surface proteins, demonstrating efficacy in depleting LAG-3 and identifying new targets for therapeutic intervention.

This paper shows that altering the timing of endosomal escape with AV5.3 improves enzymatic activity of delivered cargo compared to ZF5.3.

This paper identifies the requirements for efficient endosomal escape by ZF5.3, a mini-protein, showing pH-induced unfolding and lipid-BMP interaction are critical for its function.