Complementary modes of resistance to EGFR TKI in lung adenocarcinoma through MAPK activation and cellular plasticity
Matthew Zatzman, Àlvaro Quintanal-Villalonga, Sohrab Salehi, Nicholas Ceglia, Jake June-Koo Lee, Amanda Pupo, Christina J. Falcon, Nicole Rusk, Ignas Masilionis, Ojasvi Chaudhary, Parvathy Manoj, Ronan Chaligné, Andrew McPherson, Charles M. Rudin, Sohrab P. Shah, Helena Alexandra Yu
This study identifies MAPK activation and cellular plasticity as complementary resistance mechanisms to EGFR TKI in lung adenocarcinoma using single-nuclei RNA sequencing and clinical data.
bioRxiv · May 7, 2025 · PreprintCancer Biology