Author

Helena Alexandra Yu

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-0377-9510Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1

Frequent Co-Authors

Charles M. RudiniD· 3 shared Àlvaro Quintanal-VillalongaiD· 2 shared Andrew McPhersoniD· 2 shared Jake June-Koo LeeiD· 2 shared Nicole RuskiD· 2 shared Parvathy ManojiD· 2 shared Pedram RazaviiD· 2 shared Sohrab P. ShahiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersGenomics

Charles M. RudinORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintApr 30, 2026

Evolution of oncogene amplification across 86,000 cancer cell genomes

Jake June-Koo Lee, Sohrab Salehi, Matthew A. Myers…·Sohrab P. Shah

The paper analyzes the evolutionary trajectories of high-level copy-number amplifications in cancer cell genomes to distinguish between extrachromosomal and intrachromosomal amplification mechanisms.

2 citations

humanwhole-genome sequencing

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Cancer BiologybioRxivPreprintMay 7, 2025

Complementary modes of resistance to EGFR TKI in lung adenocarcinoma through MAPK activation and cellular plasticity

Matthew Zatzman, Àlvaro Quintanal-Villalonga, Sohrab Salehi…·Helena Alexandra Yu

This study identifies MAPK activation and cellular plasticity as complementary resistance mechanisms to EGFR TKI in lung adenocarcinoma using single-nuclei RNA sequencing and clinical data.

2 citations

humansnRNA-seq

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GenomicsbioRxivPreprintJun 27, 2020

Enhanced specificity of high sensitivity somatic variant profiling in cell-free DNA via paired normal sequencing: design, validation, and clinical experience of the MSK-ACCESS liquid biopsy assay

Angela Rose Brannon, Gowtham Jayakumaran, Monica S. Diosdado…·Ryma Benayed

The paper describes the development and clinical application of MSK-ACCESS, a liquid biopsy assay that improves the specificity of somatic variant detection in cell-free DNA by using paired normal sequencing.

7 citations

humanwhole-exome sequencing

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