Matthew Zatzman

This study uses spatial transcriptomics and single-cell analysis to reveal how MDS bone marrow microenvironments are altered, showing TGFβ dysregulation in malignant cells and immune escape mechanisms.

This study tracks clonal evolution of drug resistance in ovarian cancer using structural variants in cfDNA, finding polyclonal resistance with dominant high-fitness clones and genomic features linked to drug resistance.

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

This study identifies MAPK activation and cellular plasticity as complementary resistance mechanisms to EGFR TKI in lung adenocarcinoma using single-nuclei RNA sequencing and clinical data.

The paper identifies impaired T cell priming and KLF2-dependent quiescence in gastric cancer draining lymph nodes as mechanisms limiting immune responses.