Author

Leslie A. Spikes

University of Kansas Medical CenterORCID 0000-0002-0782-9730Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 1 Organism:rat· 1

Frequent Co-Authors

Anlun Li· 1 shared Esteban Mauricio DomingueziD· 1 shared Huan Dong· 1 shared Liang ZhengiD· 1 shared Michael J. SoaresiD· 1 shared Quan Zhang· 1 shared X. Long ZhengiD· 1 shared Xinyang ZhaoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPathology

Anlun Li

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Targeting pathogenic VWF/ADAMTS13 dysregulation attenuates CTEPH progression

Zhijian Wu, Huan Dong, Quan Zhang, Zhirong Chai, Anlun Li, Esteban Mauricio Dominguez, Xinyang Zhao, Leslie A. Spikes, Michael J. Soares, X. Long Zheng, Liang Zheng

This study identifies VWF/ADAMTS13 dysregulation as a driver of CTEPH progression and shows that targeting this axis reduces thrombosis and vascular remodeling in rat models.

bioRxiv · Jun 22, 2026 · PreprintPathology