Zhijian Wu

siProGenA: Generative siRNA Candidate Construction via Position Proposal and Guide Generation

siProGenA generates siRNA candidates by proposing positions and generating guide sequences, achieving high Hit@1 and Hit@5 scores in controlled evaluations.

Targeting pathogenic VWF/ADAMTS13 dysregulation attenuates CTEPH progression

This study identifies VWF/ADAMTS13 dysregulation as a driver of CTEPH progression and shows that targeting this axis reduces thrombosis and vascular remodeling in rat models.

NRL- and CRX-guided gene network modulates photoreceptor presynapse size and positioning during retinal development

The paper identifies genes regulated by NRL and CRX that control rod photoreceptor presynapse morphology and validates their function through knockdown and CRISPR/Cas9 approaches.