Ian A. Sigal

This study uses direct fiber modeling to capture specimen-specific 3D collagen fiber architecture and anisotropic mechanics of sclera samples under various loadings.

The paper models LC oxygenation under varying vascular and anatomical conditions, finding vessel radius and anatomical variation are most influential.

The paper compares the morphology of astrocytes in the lamina cribrosa and glial lamina across species to understand their role in glaucoma.

This study evaluates how elevated IOP affects lamina cribrosa oxygenation using experimental and computational models in monkeys, finding significant hypoxia at IOP levels above 30 mmHg.

The paper proposes an axon-centric method to quantify IOP-induced mechanical insults on retinal ganglion cell axons, revealing distinct longitudinal and transverse strain patterns.

This paper compares continuum and fiber models of soft tissues using ocular biomechanics, finding that fiber models better capture strain patterns and fiber-level deformations.