Markovian State Models uncover Casein Kinase 1 dynamics that govern circadian period
Clarisse Gravina Ricci, Jonathan M. Philpott, Megan R Torgrimson, Alfred M. Freeberg, Rajesh Narasimamurthy, Emilia Pecora de Barros, Rommie E. Amaro, David M. Virshup, James Andrew McCammon, Carrie L. Partch
This paper uses molecular dynamics simulations and Markovian State Models to analyze CK1 conformational dynamics, revealing how the tau mutant alters substrate selectivity and affects circadian period.
Biophysical Journal · Sep 18, 2025Peer-reviewedBiophysics