David M. Virshup

The paper identifies Wnt-regulated genes repressed by or independent of β-catenin in a cancer model, revealing a cis-regulatory motif involved in repression.

This paper uses molecular dynamics simulations and Markovian State Models to analyze CK1 conformational dynamics, revealing how the tau mutant alters substrate selectivity and affects circadian period.

This paper identifies FAXDC2 as a cholesterol biosynthesis enzyme that links Wnt/beta-catenin to RTK/MAPK signaling, showing its role in cancer progression and cellular differentiation.

The paper develops a structural model of PORCN, revealing its catalytic mechanism, disease-associated variants, and drug binding sites.

This study shows that Vangl2 regulates cytoneme dynamics, affecting Wnt/{beta}-catenin signaling and tissue patterning in vertebrates.

The paper identifies and functionally validates Wnt-regulated lncRNAs using in vivo models and CRISPRi screens, finding more functional lncRNAs in vivo than in vitro.

This study shows that mutating a PER2 phosphodegron in mice leads to longer circadian periods and altered molecular stability.

The paper shows Wnt/STOP signaling regulates ribosome biogenesis in Wnt-addicted cancers by modulating transcription and protein abundance of key factors.

The paper uses the RUSH system to visualize Wnt secretion from the endoplasmic reticulum to filopodia, showing WLS is rate-limiting for ER exit and filopodia enhance Wnt signaling.