AI-assisted improvement of Aspergillus oryzae β-galactosidase using an Ensemble of Protein Language Models
Andrea Trapote Fernandez, Alicia Fernández, Juan Antonio Méndez-Líter, Alicia Prieto, Jorge Barriuso, Fernando G. Osorio
This paper uses an ensemble of protein language models to identify beneficial mutations in Aspergillus oryzae β-galactosidase, improving catalytic efficiency and thermostability without supervised training.
bioRxiv · May 21, 2026 · PreprintSynthetic Biology