Fernando G. Osorio

This paper uses an ensemble of protein language models to identify beneficial mutations in Aspergillus oryzae β-galactosidase, improving catalytic efficiency and thermostability without supervised training.

The paper introduces a CRISPR/Cas9 mouse line (CARLIN) to simultaneously track lineage histories and gene expression in single cells, revealing clonal bottlenecks in hematopoietic stem cells.