Author

Miha Milek

Berlin Institute of Health at Charité - Universitätsmedizin BerlinORCID 0000-0002-0803-8439Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Markus LandthaleriD· 2 shared Ana Beatriz Oliveira Villela Silva· 1 shared Arif Bülent EkiciiD· 1 shared Armin EnsseriD· 1 shared Bastian Grewe· 1 shared David SteinbrechtiD· 1 shared Doris Jungnickl· 1 shared Emanuel WyleriD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSystems Biology

Markus LandthalerORCID

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2 papers

Recent·Most cited

Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting

David Steinbrecht, Igor Minia, Miha Milek, Johannes Meisig, Nils Blüthgen, Markus Landthaler

The paper measures mRNA flow rates between subcellular compartments in mouse embryonic stem cells and identifies nuclear retention as the rate-limiting step for many mature mRNAs.

Molecular Systems Biology · Nov 15, 2024Peer-reviewedSystems Biology

CRNKL1 is a highly selective regulator of intron-retaining HIV-1 and cellular mRNAs

Han Xiao, Emanuel Wyler, Miha Milek, Bastian Grewe, Philipp Kirchner, Arif Bülent Ekici, Ana Beatriz Oliveira Villela Silva, Doris Jungnickl, Florian Full, Marco Thomas, Markus Landthaler, Armin Ensser, Klaus Überla

The paper identifies CRNKL1 as a regulator that enhances nuclear retention of intron-retaining HIV-1 and cellular mRNAs, affecting their cytoplasmic levels.

mBio · Jan 18, 2021Peer-reviewedMicrobiology