David Steinbrecht

The paper uses Perturb-seq to identify TCF7 as a key integrator of MAPK and Wnt signaling pathways through a feedback loop with EGR1.

The paper measures mRNA flow rates between subcellular compartments in mouse embryonic stem cells and identifies nuclear retention as the rate-limiting step for many mature mRNAs.

This study uses targeted Perturb-seq to identify EGR1 and FOS as key regulators of the transcriptional RAF-MAPK response by constructing a directional interaction network.