The paper measures mRNA flow rates between subcellular compartments in mouse embryonic stem cells and identifies nuclear retention as the rate-limiting step for many mature mRNAs.

Molecular Systems Biology · Nov 15, 2024Peer-reviewedSystems Biology

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Julien Olivet, Jérémy Blavier, Simona Kostova, Sibusiso B. Maseko, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, , Erich E. Wanker

The paper presents an AI-guided pipeline for PPI drug discovery, identifying a SARS-CoV-2 inhibitor by combining experimental assays, machine learning, and virtual screening.

Molecular Systems Biology · Mar 11, 2024Peer-reviewedSystems Biology

The suppressive cap-binding-complex factor 4EIP is required for normal differentiation

Monica Cristina Terrão, Kevin Kamanyi Marucha, Elisha Mugo, Dorothea Droll, Igor Minia, Franziska Egler, Johanna Braun, CHRISTINE E. CLAYTON

This study shows that 4EIP suppresses mRNA translation in Trypanosoma brucei and is required for differentiation to stumpy forms.

Nucleic Acids Research · Aug 1, 2018Peer-reviewedMolecular Biology