Understanding the role of membrane lipids in mechanism of antimicrobial photodynamic therapy in Escherichia coli
Marta Piksa, Mariusz A. Bromke, Carlos Manuel Marques, Sigolène Lecuyer, Patricia Daira, Baptiste Fourmaux, Ifor D. W. Samuel, Katarzyna Matczyszyn, Krzysztof J Pawlik
This study shows that reducing cardiolipin in Escherichia coli increases its susceptibility to antimicrobial photodynamic therapy, suggesting cardiolipin-rich domains support stress-defense systems rather than being direct targets of oxidative damage.
bioRxiv · Feb 7, 2026 · PreprintMicrobiology