A chemical genomic screen identifies novel genetic interactors of the methylation-dependent de novo pathway of phosphatidylcholine biosynthesis in Saccharomyces cerevisiae.
Amanda Maliva, Wayne Russell Riekhof
The paper identifies 410 yeast gene deletion mutants hypersensitive to HEH, revealing 21 genes epistatically interacting with PtdCho methylation pathway enzymes.
bioRxiv · Jan 7, 2025 · PreprintCell Biology