Molecular BiologybioRxivPreprint
GLP-1(9-36) mediates the glucagonostatic effect of GLP-1 by promiscuous activation of the glucagon receptor
Claudia Guida, CAROLINE A. MIRANDA, Ingrid Wernstedt Asterholm…·Reshma D. Ramracheya
This paper identifies that GLP-1(9-36) inhibits glucagon secretion via the glucagon receptor, while GLP-1(7-36) uses the GLP-1 receptor, revealing distinct mechanisms for glucagon suppression.
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