GLP-1(9-36) mediates the glucagonostatic effect of GLP-1 by promiscuous activation of the glucagon receptor
Claudia Guida, CAROLINE A. MIRANDA, Ingrid Wernstedt Asterholm, Davide Basco, Anna Benrick, Belén Chanclón, Margarita V. Chibalina, Matthew Harris, Joely A. Kellard, Laura J. McCulloch, Joana I. Real, Nils J. G. Rorsman, Ho Yan Yeung, Frank M. Reimann, Makoto Shigeto, , Reshma D. Ramracheya
This paper identifies that GLP-1(9-36) inhibits glucagon secretion via the glucagon receptor, while GLP-1(7-36) uses the GLP-1 receptor, revealing distinct mechanisms for glucagon suppression.
bioRxiv · Apr 2, 2020 · PreprintMolecular Biology