Bernard Thorens

Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links myelin homeostasis to counterregulation and metabolic health.

This study identifies Tmem117 as an oligodendrocyte-enriched regulator of NCX activity, linking myelin homeostasis to counterregulatory response and metabolic health.

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

This study shows that autophagy regulator ATG5 protects cerebellar Purkinje cells by maintaining glycolytic activity, preventing neurodegeneration through regulation of glucose transporter 2.

Pseudospatial transcriptional gradient analysis of hypothalamic ependymal cells: towards a new tanycyte classification

The paper analyzes hypothalamic ependymal cells using single-cell RNA sequencing to classify tanycyte subpopulations and reveal their functional heterogeneity under different fasting conditions.

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

GLP-1(9-36) mediates the glucagonostatic effect of GLP-1 by promiscuous activation of the glucagon receptor

This paper identifies that GLP-1(9-36) inhibits glucagon secretion via the glucagon receptor, while GLP-1(7-36) uses the GLP-1 receptor, revealing distinct mechanisms for glucagon suppression.

Profound perturbation of the human metabolome by obesity

This study identifies metabolic and genetic signatures of obesity using metabolome analysis and whole genome sequencing in twin and volunteer cohorts, revealing clinically meaningful heterogeneity.