Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations
Alex R. Lederer, Maxine Leonardi, Lorenzo Talamanca, Daniil M. Bobrovskiy, Antonio Herrera, Colas Droin, Irina M. Khven, Hugo J. F. Carvalho, Alessandro Valente, Albert Dominguez Mantes, Pau Mulet Arabí, Luca Pinello, Félix Naef, Gioele La Manno
This paper introduces a statistical RNA velocity model that improves dynamical consistency and inference of cell cycle speed from scRNA-seq data.
Nature Methods · Oct 31, 2024Peer-reviewedSystems Biology