Alessandro Valente

The lipidomic architecture of the mouse brain

The paper maps the lipidomic architecture of the adult mouse brain at micrometric scale, revealing spatial lipid organization and its functional relevance.

Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration

This study identifies species-specific oxygen sensing as a key factor in limb regeneration, showing that reducing oxygen sensing in amphibians enhances regenerative capacity while mammals require oxygen-sensitive pathways.

Reconstituting Mouse Embryogenesis Ex Utero from Gastrulation to Fetal Development Reveals Maternally Independent Metabolic Programs

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution

The paper longitudinally profiles cerebellar organoids, benchmarks them against fetal data, and models mutations linked to autism and human brain evolution.

Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations

This paper introduces a statistical RNA velocity model that improves dynamical consistency and inference of cell cycle speed from scRNA-seq data.