Alex R. Lederer

This study identifies evolutionarily recent transcription factors that influence human cell cycle regulation by affecting gene expression and replication timing.

This paper introduces a statistical RNA velocity model that improves dynamical consistency and inference of cell cycle speed from scRNA-seq data.

The paper profiles histone modifications in adult human CNS cells, revealing epigenetic memory of developmental programs in oligodendroglia.

The paper creates a single-cell transcriptome atlas of mouse brain development, identifying over 1000 cell states and linking tumor cells to developmental states.

This study maps the single-cell transcriptomic dynamics of hESC-RPE differentiation, identifies an intermediate progenitor, and shows in vivo maturation after transplantation.

This study investigates the role of the Paf1 complex in regulating the transcriptome of Saccharomyces cerevisiae, revealing its impact on both coding and noncoding transcripts through transcriptional and post-transcriptional mechanisms.