On the correspondence of electrical and optical physiology in in vivo population-scale two-photon calcium imaging.
Peter Ledochowitsch, Lawrence Huang, Ulf Knoblich, Michael Oliver, Jérôme A. Lecoq, Clay Reid, Lu Li, Hongkui Zeng, Christof Koch A, Jack Waters, Saskia E. J. de Vries, Michael A. Buice
This study calibrates two-photon calcium imaging to recover action potentials in mice, finding that fluorescence changes are inconsistent for small spike numbers and vary by mouse line.
bioRxiv · Oct 11, 2019 · PreprintNeuroscience