Revant Gupta

The paper maps gene regulators of endothelial cell differentiation using CRISPR and single-cell RNA-seq, identifying Hippo mechanosignaling as critical for endothelial identity.

The paper maps and redesigns the MYBPC3 promoter to enhance expression and treat haploinsufficient hypertrophic cardiomyopathy.

Rosalind, a DNA foundation model, predicts variant-gene regulatory relationships without proximity bias, identifying distal genes as more impactful in osteoporosis.

This paper introduces a latent state-space Markov model for kinetic clustering and lineage inference in scRNA-seq data, demonstrating its ability to distinguish functional from transitional cell-states during differentiation.

Cytopath infers differentiation trajectories using RNA velocity data, outperforming existing methods in reconstructing complex differentiation processes.