Author

Aaron Renberg

University of MichiganORCID 0000-0002-8782-9342Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Adam S. HelmsiD· 3 shared Joshua K. MeisneriD· 3 shared Sabrina Friedline· 3 shared Yao-Chang TsaniD· 3 shared Elizabeth D. Hughes· 2 shared Eric D. SmithiD· 2 shared Jacob Otto KitzmaniD· 2 shared Jennasea LicataiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Adam S. HelmsORCID

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Author profile →

4 papers

Recent·Most cited

Mapping and rewiring the MYBPC3 promoter for rescue of haploinsufficiency driven hypertrophic cardiomyopathy

Aaron Renberg, Savannah Coppersmith, Owen L. Merritt, Yao-Chang Tsan, Esraa Ismail, Jennasea Licata, Maya U. Sheth, Revant Gupta, Anshul Bharat Kundaje, Sabrina Friedline, Hayden C. Helms, Elizabeth D. Hughes, Zachary Thomas Freeman, George Powell, James S. Ware, , Adam S. Helms

The paper maps and redesigns the MYBPC3 promoter to enhance expression and treat haploinsufficient hypertrophic cardiomyopathy.

bioRxiv · Sep 22, 2026 · PreprintMolecular Biology

Genomic Engineering of Gene Dosage: A Generalizable Framework for Modeling Haploinsufficiency-Mediated Human Disorders through Splicing Modulation

Eric D. Smith, Joshua K. Meisner, Abbey Bullard, Connor Ward, Jennasea Licata, Cathy Smith, Colleen M. Kelly, Zachary T LaRochelle, Sabrina Friedline, Aaron Renberg, Riley Yucius, Jesse Lange, Elizabeth D. Hughes, Thomas L. Saunders, Zachary Thomas Freeman, , Adam S. Helms

This paper introduces a framework to model haploinsufficiency-mediated human disorders by modulating gene dosage through splicing, demonstrating its application in creating accurate animal models for cardiomyopathies.

bioRxiv · Sep 22, 2026 · PreprintGenetics

Desmoplakin Haploinsufficiency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional Activation

Eric D. Smith, Karen Jin, Brianna Ferguson, Yao-Chang Tsan, Samuel J. DePalma, Joshua K. Meisner, Aaron Renberg, Kenneth C Bedi, Sabrina Friedline, Kenneth B. Margulies, Brendon M. Baker, Adam S. Helms

This study shows that DSP haploinsufficiency causes cell-cell adhesion failure in cardiomyopathy and that increasing DSP expression rescues this defect.

bioRxiv · Jun 1, 2025 · PreprintGenetics

The human disease gene CLEC16A encodes an intrinsically disordered protein region required for mitochondrial quality control

Morgan A. Gingerich, Xueying Liu, Biaoxin Chai, Gemma L. Pearson, Michael P. Vincent, Tracy Stromer, Jie Zhu, Vaibhav Sidarala, Aaron Renberg, Debashish Sahu, Daniel J. Klionsky, Santiago D. Schnell, Scott A. Soleimanpour

This study identifies an intrinsically disordered protein region in CLEC16A critical for mitochondrial quality control and diabetes prevention.

bioRxiv · Sep 3, 2021 · PreprintMolecular Biology