Gilles Gut

Live single-molecule imaging reveals global shifts in mRNA mobility during human stem cell differentiation

The paper tracks mRNA mobility during human stem cell differentiation and finds that mRNA dynamics shift towards constrained patterns as cells acquire identity.

Morphodynamics of human early brain organoid development

The paper uses live imaging and single-cell transcriptomics to study how extracellular matrix influences brain organoid development and regionalization.

pmVAE: Learning Interpretable Single-Cell Representations with Pathway Modules

pmVAE learns interpretable single-cell representations by incorporating pathway structure, improving detection of perturbation-targeted pathways in single-cell RNA-seq data.

Cytopath: Simulation based inference of differentiation trajectories from RNA velocity fields

Cytopath infers differentiation trajectories using RNA velocity data, outperforming existing methods in reconstructing complex differentiation processes.